4.3.1E Evaluate the impact of the Columbian Exchange on American Indian groups, African slaves and European settlers, including agriculture, trade, culture, military alliances, control of territory, and the sudden and significant decline of indigenous peoples.
4.4.2B Identify the major economic activities of each region of the United States by comparing how people satisfy their basic needs through the production of goods and services.
4.4.2C Describe the relative location of natural resources, such as fossil fuels, minerals and soils, and their relationship to each region's major economic activities, including agriculture, manufacturing, transportation, energy, and services.
4.4.3 Explain how economic activities can threaten the physical environment.
4.4.3A Identify ways in which humans can change ecosystems, such as clearing forests, draining wetlands, and diverting waterways, by examining present-day issues related to the use of resources.
4.4.3B Identify examples of changes in land use in local communities and how the physical environment can be stressed by human activities.